Presence of the Tet M determinant in a clinical isolate of Acinetobacter baumannii.
نویسندگان
چکیده
The tet(M) gene encodes a protein which is related to tetracycline ribosomal protection, one of the mechanisms of tetracycline resistance. A tet(M) gene that is 100% homologous to the tet(M) gene of Staphylococcus aureus has been found in a clinical isolate of Acinetobacter baumannii, which also carries the tet(A) gene encoding a tetracycline efflux pump.
منابع مشابه
Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii.
A genomic library from one clinical isolate of Acinetobacter baumannii was obtained to find genes responsible for tetracycline resistance. Escherichia coli DH5alpha-MDR transformants, selected on Mueller-Hinton agar supplemented with tetracycline 18 mg/L, were thoroughly characterized. In one clone, with an insert of 7,070 bp, it was found that the resistance to tetracycline was mediated by the...
متن کاملPhenotypic and genotypic characteristics of tetracycline resistant Acinetobacter baumannii isolates from nosocomial infections at Tehran hospitals
Objective(s):To date, the most important genes responsible for tetracycline resistance among Acinetobacter baumannii isolates have been identified as tet A and tet B. This study was carried out to determine the rate of resistance to tetracycline and related antibiotics, and mechanisms of resistance. Materials and Methods: During the years 2010 and 2011, a total of 100 A. baumannii isolates we...
متن کاملDetection of Integrons in Acinetobacter Baumannii Strains Isolated from the Nosocomial Infections of Ahvaz City and their Relation with the Resistance Pattern
Background and Aims: Acinetobacter baumannii is regarded as an important nosocomial pathogen around the world, especially in the intensive care unit that today seems to be resistant to the most antibiotics. Therefore, this study aimed to trace classes 1, 2, and 3 integrin in the isolates resistant to Acinetobacter baumannii. Materials and Methods: In this descriptive study, Acinetobacter bau...
متن کاملPhonotypic Investigation of Biofilm Formation and Determination of Presence of bap and blaOXA-51 Genes in Acinetobacter baumannii From Clinical Specimens in Tehran
Background: Acinetobacter baumannii is a non-fermentative gram-negative coccobacill that has high level of resistance to antimicrobial agents. Biofilm formation is an important feature of most clinical isolates of Acinetobacter spp, this led to higher resistance to antibiotics. The current study aimed to assess the ability of biofilm production and to determine the frequency of bap gene in cl...
متن کاملStereochemical Trajectories of a Two-Component Regulatory System PmrA/B in a Colistin-Resistant Acinetobacter baumannii Clinical Isolate
Background: There is limited information on the 3D prediction and modeling of the colistin resistance-associated proteins PmrA/B TCS in Acinetobacter baumannii. We aimed to evaluate the stereochemical structure and domain characterization of PmrA/B in an A. baumannii isolate resistant to high-level colistin, using bioinformatics tools. Methods: The species of the isolate and its susceptibility ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 47 7 شماره
صفحات -
تاریخ انتشار 2003